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KMID : 0388419930030010151
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Konkuk Journal of Medical Sciences
1993 Volume.3 No. 1 p.151 ~ p.164
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The Ultrastructural Changes of Hypothalamus and Putamen by In-Situ Perfusion with L-Glutamate, Glycine and Kynurenate in Rats
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Abstract
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Rat brains were treated with in-situ perfusion to investigate the presence and in-vivo role of Glutamate(Glu) receptor and Glycine 2 (Gly2) receptor in hypothalamus and putamen.
The changes by perfusion with Glu was similar to those receiving diect stereotaxical injection of Glu, Exhhibiting axon-sparing effect. The acute reaction of swelling of dendrites in hypothalamus and putamen was prominent. The changes by
perfusion
with
Gly was similar to those with Glu, exhibiting swelling of dendrites in hypothalamus and putamen. The result to Gly in hypothalamus and putamen apparently represents excitotoxic reaction while Glycine 1(gly1) receptor in brainstem and spinal cord
play
the role of inhibitory site.
Dendrites exhibiting excitotoxic reaction to Gly are fewer than those to Glu. The Glu administration combined with Gly did not cause synergistic excitotoxic effect Kynurenate(Kyn), competitive antagonist, did not exhibit apparent protective
effect.
So
it is suggested that the Glu and Gly2 receptors in hypothalamus and putamen are exhibiting excitotoxic reaction to sufficiently high Glu and Gly concentration, and are excitatory sites.
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KEYWORD
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